Alcohol/Substance
Dependence
SYMPTOMS
A maladaptive pattern
of substance use, leading to clinically significant impairment or distress,
as manifested by three (or more) of the following, occurring at any time in
the same 12-month period:
1.
tolerance,
as defined by either of the following:
2.
withdrawal,
as manifested by either of the following:
3.
the
substance is often taken in larger amounts or over a longer period than was
intended
4.
there is a
persistent desire or unsuccessful efforts to cut down or control substance
use
5.
a great deal
of time is spent in activities necessary to obtain the substance (e.g.,
visiting multiple doctors or driving long distances), use the substance
(e.g., chain-smoking), or recover from its effects
6.
important
social, occupational, or recreational activities are given up or reduced
because of substance use
7.
the
substance use is continued despite knowledge of having a persistent or
recurrent physical or psychological problem that is likely to have been
caused or exacerbated by the substance (e.g., current cocaine use despite
recognition of cocaine-induced depression, or continued drinking despite
recognition that an ulcer was made worse by alcohol consumption)
Criteria summarized
from:
American Psychiatric Association. (1994). Diagnostic and statistical
manual of mental disorders, fourth edition. Washington, DC: American
Psychiatric Association.
Alcohol Abuse & Dependence
TREATMENT
Detoxification:
It is
impossible to treat alcohol dependence in patients who continue to use
alcohol. The patient must be detoxified before any meaningful therapy can
begin for other emotional problems. Usually this detoxification can be done
as an outpatient. However, the following are the indications for inpatient
detoxification:
-
Failure of outpatient
detoxification
-
Lack of motivation
-
Strong denial
-
Severe impairment
-
Insufficient
psychosocial supports
-
Living situation
encourages continued substance abuse
-
Risk of medically
dangerous withdrawal syndromes
-
Coexisting medical or
psychiatric illness requiring close observation
Because of the many medical complications of alcohol
withdrawal, a complete physical examination with appropriate laboratory
tests is mandatory, with special attention to the liver and nervous system.
Patients withdrawing from alcohol who exhibit any withdrawal
phenomena should receive a benzodiazepine (such as chlordiazepoxide or
diazepam). Anticonvulsant medication is not useful in preventing or treating
alcohol withdrawal convulsions; the use of chlordiazepoxide or diazepam is
generally effective.
A high-calorie, high-carbohydrate diet supplemented by
multivitamins is important. Dehydration must be corrected with fluids by
mouth or intravenously.
Alcoholic patients in severe withdrawal should never be
physically restrained as they may fight the restraints to exhaustion. When
patients are disorderly and uncontrollable, a seclusion room can be used.
The need for warm verbal support is imperative in the treatment of severe
alcohol withdrawal. Patients in severe withdrawal are very confused and
frightened - yet can dramatically calm when given sufficient verbal support.
Restrict access to addicting substances:
Following
detoxification, alcohol should be removed from the patient's home, and all
prescriptions written by other physicians should be discontinued. Until the
patient is stronger, all family or friends that drink heavily or use illicit
drugs should be avoided.
Teach the disease model of addiction:
The patient and
the family should be educated that addiction is an medical illness - not a
moral failing. An alcoholic can never go back to drinking. In general,
controlled drinking (e.g., one drink per weekend) carries a high risk of
relapse. Any treatment for alcoholism must be based on total abstinence.
Likewise, ALL addictive drugs should be avoided (unless they are clearly
indicated for acute pain or time-limited acute anxiety).
Addictions, like many other medical disorders, are relapsing
conditions that require a long-term commitment to therapy. Thus progress in
therapy is often "two-steps-forward-and-one-step-back", but the patient
should not be abandoned because of a temporary "slip" back into addiction.
Relapses should be dealt with in a nonjudgmental manner, and detoxification
should be arranged rapidly.
Treat associated psychiatric problems:
Alcohol may
have been a self-treatment for another psychiatric disorder. This is
especially true of addicted patients who use alcohol to treat their
Psychotic Disorder, Mood Disorder, Anxiety Disorder, or Personality
Disorder. Many of these coexisting psychiatric disorders have effective
medical treatments which should be given.
Do unscheduled alcohol blood tests:
Periodic blood
tests for alcohol can be essential in identifying relapse. It is essential
that these blood tests be unscheduled (to minimize the risk of "cheating").
Encourage exercise:
It is important to
stress the importance of regular exercise (lasting more than 20 minutes at a
time) as an alternative to craving alcohol. It is hoped that the patient
will develop a dependency on exercise to replace the former dependency on
alcohol as a "stress reliever".
The standard treatment regime for alcohol withdrawal is:
-
Chlordiazepoxide:
25-100 mg
orally four times on the first day (with a 20% decrease in dose over a 5-7
day period). This dose may have to be doubled in severe alcohol withdrawal
(if agitation, tremors, or change in vital signs develop). Should status
epilepticus develop; diazepam, 10 mg intravenously, usually will abort the
seizure. To prevent further status postwithdrawal seizures, magnesium
sulfate may be given (1 g intramuscularly every 6 hours for 2 days).
-
Multivitamin:
one per day. For
severe alcoholics, it is imperative to supplement this with thiamine 100
mg and folic acid 1 mg - both orally four times daily for at least two
weeks. These vitamins prevent the dangerous progression of alcohol
withdrawal into Korsakoff's psychosis and Wernicke's encephalopathy.
The chlordiazepoxide or diazepam may have to be prescribed
for weeks or even months to control the anxiety, restlessness, and insomnia
seen in the initial stage of abstinence. The physician must carefully
monitor this antianxiety drug therapy to prevent over-medication or
addiction. With careful monitoring, the risk of the alcoholic becoming
addicted to an antianxiety drug is remote.
Disulfiram (Antabuse) competitively inhibits the enzyme
aldehyde dehydrogenase, so that even a single drink usually causes a toxic
reaction due to acetaldehyde accumulation in the blood. Administration of
the drug should not begin until 24 hours after the patient's last drink. The
physician must warn the patient about the drug or for as long as 2 weeks
thereafter. Those who drink while taking disulfiram turn purple, become
severely ill for 30 to 60 minutes (or longer) and often vomit. Patients on
disulfiram may also have this same response to alcohol ingested in
mouthwash, wine sauces or vinegars, or even to inhaled alcohol vapors from
aftershave lotions. Disulfiram may also exacerbate psychotic symptoms in
schizophrenic patients (but this is uncommon).
Disulfiram can be of critical importance in helping the
alcoholic to make the essential decision to stop drinking. There should be
nothing surreptitious about the use of disulfiram (i.e., no slipping the
drug into the coffee by the spouse). It should be discussed with the
patient, with full disclosure of its side effects and dangers. The initial
dosage (after a minimum of 24 hours' abstention from alcohol) is 500 mg/d in
a single dose in the morning. This can be decreased to a maintenance dose of
250 mg/d, continued indefinitely.
Disulfiram frees the alcoholic from ruminating as to whether
he should or should not have a drink and prevents the relapses that usually
follow a sudden and impulsive first drink.
Studies of alcoholic patients indicated that as many as 30
percent may suffer from a Major Depression beyond the detoxification period.
These patients often benefit from antidepressant medication (in doses
similar to those prescribed for other clinically depressed patients). The
antidepressants can be used without difficulty in patients taking disulfiram.
Lithium has also been used with some success.
Hospitalization is not usually necessary or even desirable
unless there are serious medical complications during alcohol withdrawal.
Most alcoholics can be safely withdrawn from alcohol at home or at a
detoxification center.
Antipsychotic drugs are best avoided because they may
increase the risk of alcohol withdrawal seizures. Antipsychotic drugs are
only used for the rare cases of alcoholic hallucinosis that fail to respond
to treatment with benzodiazepines.
Arrange follow-up treatment:
If an alcoholic
is to remain alcohol-free, follow-up treatment, usually with psychiatric
help and resort to community resources, is often vital. The patient must be
seen regularly to monitor continued abstinence and adjustment.
Research is showing that patient factors such as having a
stable family, stable job, less sociopathy, less psychopathology, and a
negative family history for alcoholism are more powerful predictors of
positive outcome that is the type of treatment (Frances et al. 1984). This
research could be interpreted to mean that follow-up treatment is most
needed for alcoholic patients with an unstable family, unstable job, more
sociopathy, more psychopathology, and a positive family history for
alcoholism.
Confront denial gradually:
Aggressive
confrontation too early in treatment may increase, rather than decrease, the
patient's denial of having a problem. Initially, all that the patient has to
agree to is detoxification (usually done to placate the family or the
physician).
The best way to confront the patient's denial of addiction is
to challenge him to "prove" that he's not addicted by going on a one month
trial period of abstinence. A successful trial period of abstinence may help
the patient feel so much better that continued abstinence becomes easier. An
unsuccessful trail period of abstinence proves that the alcohol use is out
of control, and the therapist must then confront the patient's denial more
vigorously.
Focus psychotherapy on the patient's addiction:
Psychotherapy
is most successful when it focuses on the alcoholic's drinking. The drinking
itself - past, present, and future consequences - must be given firm
emphasis. Patients who insist that they need to solve their emotional
problems before they stop using alcohol must be told that the alcohol is the
main problem, and that other emotional problems can not be adequately
treated until they first stop using alcohol.
Involve family and friends:
The therapist
must involve the patient's family or friends as allies in the patient's
treatment. Family and friends are often aware of relapses that are concealed
by the patient. Research has shown that patients that are encouraged or even
coerced into treatment by family or friends are more likely to remain in
treatment and have a better outcome than those who are not so pressured.
Therapists should routinely refer alcoholics to A.A. as part
of a multiple treatment approach. Although Alcoholics Anonymous does not
appeal to all alcoholics, it is obvious that the AA approach has been
extremely successful with many.
A.A. meetings provide members with acceptance, understanding,
forgiveness, confrontation, and a means for positive identification. New A.A.
members are asked to admit to a problem, give up a sense of personal control
over the disease, do a personal assessment, make amends, and help others.
Telephone numbers are exchanged, and new members pick "sponsors" (more
experienced members who guide them through their recovery).
Al-Anon is an organization for the spouses of alcoholics that
is organized along the same lines as Alcoholic Anonymous. Alateen has been
developed for the children of alcoholics so that they may better understand
their parents' alcoholism.
A residential center or halfway house is an important
treatment resource for the alcoholic newly discharged from inpatient care.
The halfway house provides emotional support, counselling and progressive
entry into society.
Behavior therapy teaches the alcoholic other ways to reduce
anxiety. Relaxation training, assertiveness training, self-control skills,
and new strategies to master the environment are emphasized.
Trials of aversive conditioning - apomorphine and emetine to
induce vomiting, electrical stimulation to produce pain - are no longer
widely used in the treatment of alcoholism.
Reprinted from
Internet Mental Health, Copyright © 1995 by Phillip W. Long, M.D.

Substance Abuse &
Dependence
TREATMENT
Medical Treatment
Basic Principles
The principles of cocaine rehabilitation are similar to
treatment of alcoholism or sedativism. Detoxification is a prerequisite in
the treatment of this disorder.
Antianxiety Drugs
Severe cocaine-induced agitation can be treated with diazepam
(Valium) 5 to 10 mg every 3 hours IM or PO. Tachyarrhythmias can be treated
with propranolol (Inderol) 10 to 20 mg PO every 4 hours.
Antidepressant Drugs
In preliminary tests, imipramine and desipramine attenuated
cocaine euphoria and craving.
Lithium
Lithium has been reported to block cocaine euphoric effects,
though recent evidence suggests lithium is effective only in bipolar or
cyclothymic patients.
Other Drugs
Vitamin C (0.5 g PO every 6 hours) may increase urinary
excretion by acidifying urine.
Methylphenidate has not been found to be useful in those
cocaine abusers who do not have preexisting attention deficit disorder.
Hospitalization
Usually cocaine dependent patients are best treated as
outpatients. Inpatient hospitalization may be needed for severe crash
symptoms, suicide ideation, psychotic symptoms, or failure in outpatient
treatment.
Psychosocial Treatment
Basic Principles
If a user is to remain drug-free, follow-up treatment,
usually with psychiatric help and resort to community resources, is vital.
Life-style changes such as avoiding people, places, and
things related to cocaine use should be encouraged.
Initial psychosocial treatment should focus on confronting
denial, teaching the disease concept of addictions, fostering an
identification as a recovering person, recognition of the negative
consequences of cocaine abuse, avoiding situational and intrapsychic cues
that stimulate craving, and formulation of support plans.
Drug urine tests should be used to ensure compliance.
Treatment outcome is affected more by such factors as
employment status, family support, and degree of antisocial features than by
initial motivation for treatment.
Psychotherapy
It is likely that some heavy cocaine users, like other heavy
drug users, suffer from chronic anxiety, depression, or feelings of
inadequacy. In these cases, the drug abuse is a symptom rather than the
central problem. These cases can benefit from psychotherapy.
Psychotherapy is useful when it focuses on the reasons for
the patient's drug abuse. The drug abuse itself - past, present, and future
consequences - must be given firm emphasis. Involving an interested and
cooperative parent or spouse in conjoint therapy is often very beneficial.
The therapist must be watchful for return of cocaine-related
activities, attitudes, friendships, and paraphernalia. Alcohol and other
mood-altering drugs should be avoided, since they may disinhibit behavior
and lead to relapse. Concurrent Axis I or II psychiatric disorders should be
treated with attention to the interaction with cocaine disorder.
Treatment of clearly defined attention deficit disorder or
bipolar or unipolar depression should proceed along with attention to the
addiction.
Cocaine Anonymous
A new self-help group, Cocaine Anonymous, has started. It is
patterned after Alcohol Anonymous and Narcotics Anonymous.
Medical Treatment
Basic Principles
Usually adverse effects of marijuana intoxication do not lead
to professional attention. There is no adequately documented case of a
fatality in a human being. Pure marijuana abuse rarely requires inpatient or
pharmacological treatment, and detoxification is not necessary.
Since marijuana may be one of many drugs abused, total
abstinence from all psychoactive substances should be the goal of therapy.
Periodic urine testing should be used to monitor abstinence.
Cannabinoids can be detected in the urine up to 21 days after
abstinence in chronic abusers due to fat redistribution; however, one to
five days is the normal urine positive period. Thus, beginning drug
monitoring needs to be interpreted accordingly.
Antianxiety Drugs
Antianxiety drugs are occasionally needed to treat severe
cannabis-induced anxiety or panic.
If the patient was using cannabis for anxiety reduction, an
antianxiety drug should be considered as substitution therapy.
Antipsychotic Drugs
Antipsychotic drugs are occasionally needed to treat
protracted, cannabis-induced psychosis.
Antidepressant Drugs
If the patient was using cannabis for alleviation of
depression, an antidepressant should be considered as substitution therapy.
Psychosocial Treatment
Basic Principles
If a user is to remain drug-free, follow-up treatment,
usually with psychiatric help and resort to community resources, is vital.
Life-style changes such as avoiding people, places, and
things related to cannabis use should be encouraged.
Initial psychosocial treatment should focus on confronting
denial, teaching the disease concept of addictions, fostering an
identification as a recovering person, recognition of the negative
consequences of cannabis abuse, avoiding situational and intrapsychic cues
that stimulate craving, and formulation of support plans.
Drug urine tests should be used to ensure compliance.
Educating patients about the amotivational syndrome and other
complications of cannabis abuse may dissuade some from using cannabis. Often
the patient does not realize the full extent of his amotivational syndrome
until he stops using the drug and notices the improvement.
Psychotherapy
It is likely that some heavy cannabis users, like other heavy
drug users, suffer from chronic anxiety, depression, or feelings of
inadequacy. In these cases, the drug abuse is a symptom rather than the
central problem. These cases can benefit from psychotherapy.
Psychotherapy is useful when it focuses on the reasons for
the patient's drug abuse. The drug abuse itself - past, present, and future
consequences - must be given firm emphasis. Involving an interested and
cooperative parent or spouse in conjoint therapy is often very beneficial.
In the adolescent, cannabis dependence often hides poor
self-esteem, depression, severe family problems, and learning disorders.
These issues must be addressed in therapy. Generally, a nonjudgmental,
honest, steady, and firm approach is needed with adolescence.
Behavior Therapy
Behavior therapy teaches the cannabis drug user other ways to
reduce anxiety. Relaxation training, assertiveness training, self-control
skills, and new strategies to master the environment are emphasized.
Reprinted from Internet Mental Health, Copyright © 1995 by Phillip W.
Long, M.D.
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